TY - JOUR
T1 - Integrative functional genomic analysis of human brain development and neuropsychiatric risks
AU - BrainSpan Consortium
AU - PsychENCODE Consortium
AU - PsychENCODE Developmental Subgroup
AU - Li, Mingfeng
AU - Santpere, Gabriel
AU - Kawasawa, Yuka Imamura
AU - Evgrafov, Oleg V.
AU - Gulden, Forrest O.
AU - Pochareddy, Sirisha
AU - Sunkin, Susan M.
AU - Li, Zhen
AU - Shin, Yurae
AU - Zhu, Ying
AU - Sousa, André M.M.
AU - Werling, Donna M.
AU - Kitchen, Robert R.
AU - Kang, Hyo Jung
AU - Pletikos, Mihovil
AU - Choi, Jinmyung
AU - Muchnik, Sydney
AU - Xu, Xuming
AU - Wang, Daifeng
AU - Lorente-Galdos, Belen
AU - Liu, Shuang
AU - Giusti-Rodríguez, Paola
AU - Won, Hyejung
AU - De Leeuw, Christiaan A.
AU - Pardiñas, Antonio F.
AU - Reimers, M. A.
AU - Willsey, A. J.
AU - Oldre, A.
AU - Szafer, A.
AU - Camarena, A.
AU - Cherskov, A.
AU - Charney, A. W.
AU - Abyzov, A.
AU - Kozlenkov, A.
AU - Safi, A.
AU - Jones, A. R.
AU - Ashley-Koch, AE
AU - Ebbert, A.
AU - Price, A. J.
AU - Sekijima, A.
AU - Kefi, A.
AU - Bernard, A.
AU - Amiri, A.
AU - Sboner, A.
AU - Clark, A.
AU - Jaffe, A. E.
AU - Tebbenkamp, A. T.N.
AU - Sodt, A. J.
AU - Guillozet-Bongaarts, AL
AU - Nairn, A. C.
N1 - Publisher Copyright:
© 2018 American Association for the Advancement of Science. All rights reserved.
PY - 2018/12/14
Y1 - 2018/12/14
N2 - To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics.We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
AB - To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics.We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
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UR - http://www.scopus.com/inward/citedby.url?scp=85058377382&partnerID=8YFLogxK
U2 - 10.1126/science.aat7615
DO - 10.1126/science.aat7615
M3 - Article
C2 - 30545854
AN - SCOPUS:85058377382
SN - 0036-8075
VL - 362
JO - Science
JF - Science
IS - 6420
M1 - 1264
ER -