Integrative biology of exercise

John A. Hawley, Mark Hargreaves, Michael J. Joyner, Juleen R. Zierath

Research output: Contribution to journalReview articlepeer-review

412 Scopus citations


Exercise represents a major challenge to whole-body homeostasis provoking widespread perturbations in numerous cells, tissues, and organs that are caused by or are a response to the increased metabolic activity of contracting skeletal muscles. To meet this challenge, multiple integrated and often redundant responses operate to blunt the homeostatic threats generated by exercise-induced increases in muscle energy and oxygen demand. The application of molecular techniques to exercise biology has provided greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses, and recent discoveries offer perspectives on the mechanisms by which muscle "communicates" with other organs and mediates the beneficial effects of exercise on health and performance.

Original languageEnglish (US)
Pages (from-to)738-749
Number of pages12
Issue number4
StatePublished - Nov 6 2014

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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