Integrating genomic resources with electronic health records using the HL7 infobutton standard

Bret S.E. Heale; Casey Lynnette Overby; Guilherme Del Fiol; Wendy S. Rubinstein; Donna R. Maglott; Tristan H. Nelson; Aleksandar Milosavljevic; Christa L. Martin; Scott R. Goehringer; Robert R. Freimuth; Marc S. Williams

doi:10.4338/ACI-2016-04-RA-0058

Integrating genomic resources with electronic health records using the HL7 infobutton standard

Bret S.E. Heale, Casey Lynnette Overby, Guilherme Del Fiol, Wendy S. Rubinstein, Donna R. Maglott, Tristan H. Nelson, Aleksandar Milosavljevic, Christa L. Martin, Scott R. Goehringer, Robert R. Freimuth, Marc S. Williams

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: The Clinical Genome Resource (ClinGen) Electronic Health Record (EHR) Workgroup aims to integrate ClinGen resources with EHRs. A promising option to enable this integration is through the Health Level Seven (HL7) Infobutton Standard. EHR systems that are certified according to the US Meaningful Use program provide HL7-compliant infobutton capabilities, which can be leveraged to support clinical decision-making in genomics. Objectives: To integrate genomic knowledge resources using the HL7 infobutton standard. Two tactics to achieve this objective were: (1) creating an HL7-compliant search interface for ClinGen, and (2) proposing guidance for genomic resources on achieving HL7 Infobutton standard accessibility and compliance. Methods: We built a search interface utilizing OpenInfobutton, an open source reference implementation of the HL7 Infobutton standard. ClinGen resources were assessed for readiness towards HL7 compliance. Finally, based upon our experiences we provide recommendations for publishers seeking to achieve HL7 compliance. Results: Eight genomic resources and two sub-resources were integrated with the ClinGen search engine via OpenInfobutton and the HL7 infobutton standard. Resources we assessed have varying levels of readiness towards HL7-compliance. Furthermore, we found that adoption of standard terminologies used by EHR systems is the main gap to achieve compliance. Conclusion: Genomic resources can be integrated with EHR systems via the HL7 Infobutton standard using OpenInfobutton. Full compliance of genomic resources with the Infobutton standard would further enhance interoperability with EHR systems.

Original language	English (US)
Pages (from-to)	817-831
Number of pages	15
Journal	Applied clinical informatics
Volume	7
Issue number	3
DOIs	https://doi.org/10.4338/ACI-2016-04-RA-0058
State	Published - 2016

Keywords

Clinical decision support
Clinical information systems
Genetics
HL7
Standards adoption

ASJC Scopus subject areas

Health Informatics
Computer Science Applications
Health Information Management

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Heale, B. S. E., Overby, C. L., Del Fiol, G., Rubinstein, W. S., Maglott, D. R., Nelson, T. H., Milosavljevic, A., Martin, C. L., Goehringer, S. R., Freimuth, R. R., & Williams, M. S. (2016). Integrating genomic resources with electronic health records using the HL7 infobutton standard. Applied clinical informatics, 7(3), 817-831. https://doi.org/10.4338/ACI-2016-04-RA-0058

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title = "Integrating genomic resources with electronic health records using the HL7 infobutton standard",

abstract = "Background: The Clinical Genome Resource (ClinGen) Electronic Health Record (EHR) Workgroup aims to integrate ClinGen resources with EHRs. A promising option to enable this integration is through the Health Level Seven (HL7) Infobutton Standard. EHR systems that are certified according to the US Meaningful Use program provide HL7-compliant infobutton capabilities, which can be leveraged to support clinical decision-making in genomics. Objectives: To integrate genomic knowledge resources using the HL7 infobutton standard. Two tactics to achieve this objective were: (1) creating an HL7-compliant search interface for ClinGen, and (2) proposing guidance for genomic resources on achieving HL7 Infobutton standard accessibility and compliance. Methods: We built a search interface utilizing OpenInfobutton, an open source reference implementation of the HL7 Infobutton standard. ClinGen resources were assessed for readiness towards HL7 compliance. Finally, based upon our experiences we provide recommendations for publishers seeking to achieve HL7 compliance. Results: Eight genomic resources and two sub-resources were integrated with the ClinGen search engine via OpenInfobutton and the HL7 infobutton standard. Resources we assessed have varying levels of readiness towards HL7-compliance. Furthermore, we found that adoption of standard terminologies used by EHR systems is the main gap to achieve compliance. Conclusion: Genomic resources can be integrated with EHR systems via the HL7 Infobutton standard using OpenInfobutton. Full compliance of genomic resources with the Infobutton standard would further enhance interoperability with EHR systems.",

keywords = "Clinical decision support, Clinical information systems, Genetics, HL7, Standards adoption",

author = "Heale, {Bret S.E.} and Overby, {Casey Lynnette} and {Del Fiol}, Guilherme and Rubinstein, {Wendy S.} and Maglott, {Donna R.} and Nelson, {Tristan H.} and Aleksandar Milosavljevic and Martin, {Christa L.} and Goehringer, {Scott R.} and Freimuth, {Robert R.} and Williams, {Marc S.}",

note = "Publisher Copyright: {\textcopyright} Schattauer 2016.",

year = "2016",

doi = "10.4338/ACI-2016-04-RA-0058",

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AU - Heale, Bret S.E.

AU - Overby, Casey Lynnette

AU - Del Fiol, Guilherme

AU - Rubinstein, Wendy S.

AU - Maglott, Donna R.

AU - Nelson, Tristan H.

AU - Milosavljevic, Aleksandar

AU - Martin, Christa L.

AU - Goehringer, Scott R.

AU - Freimuth, Robert R.

AU - Williams, Marc S.

N1 - Publisher Copyright: © Schattauer 2016.

PY - 2016

Y1 - 2016

N2 - Background: The Clinical Genome Resource (ClinGen) Electronic Health Record (EHR) Workgroup aims to integrate ClinGen resources with EHRs. A promising option to enable this integration is through the Health Level Seven (HL7) Infobutton Standard. EHR systems that are certified according to the US Meaningful Use program provide HL7-compliant infobutton capabilities, which can be leveraged to support clinical decision-making in genomics. Objectives: To integrate genomic knowledge resources using the HL7 infobutton standard. Two tactics to achieve this objective were: (1) creating an HL7-compliant search interface for ClinGen, and (2) proposing guidance for genomic resources on achieving HL7 Infobutton standard accessibility and compliance. Methods: We built a search interface utilizing OpenInfobutton, an open source reference implementation of the HL7 Infobutton standard. ClinGen resources were assessed for readiness towards HL7 compliance. Finally, based upon our experiences we provide recommendations for publishers seeking to achieve HL7 compliance. Results: Eight genomic resources and two sub-resources were integrated with the ClinGen search engine via OpenInfobutton and the HL7 infobutton standard. Resources we assessed have varying levels of readiness towards HL7-compliance. Furthermore, we found that adoption of standard terminologies used by EHR systems is the main gap to achieve compliance. Conclusion: Genomic resources can be integrated with EHR systems via the HL7 Infobutton standard using OpenInfobutton. Full compliance of genomic resources with the Infobutton standard would further enhance interoperability with EHR systems.

AB - Background: The Clinical Genome Resource (ClinGen) Electronic Health Record (EHR) Workgroup aims to integrate ClinGen resources with EHRs. A promising option to enable this integration is through the Health Level Seven (HL7) Infobutton Standard. EHR systems that are certified according to the US Meaningful Use program provide HL7-compliant infobutton capabilities, which can be leveraged to support clinical decision-making in genomics. Objectives: To integrate genomic knowledge resources using the HL7 infobutton standard. Two tactics to achieve this objective were: (1) creating an HL7-compliant search interface for ClinGen, and (2) proposing guidance for genomic resources on achieving HL7 Infobutton standard accessibility and compliance. Methods: We built a search interface utilizing OpenInfobutton, an open source reference implementation of the HL7 Infobutton standard. ClinGen resources were assessed for readiness towards HL7 compliance. Finally, based upon our experiences we provide recommendations for publishers seeking to achieve HL7 compliance. Results: Eight genomic resources and two sub-resources were integrated with the ClinGen search engine via OpenInfobutton and the HL7 infobutton standard. Resources we assessed have varying levels of readiness towards HL7-compliance. Furthermore, we found that adoption of standard terminologies used by EHR systems is the main gap to achieve compliance. Conclusion: Genomic resources can be integrated with EHR systems via the HL7 Infobutton standard using OpenInfobutton. Full compliance of genomic resources with the Infobutton standard would further enhance interoperability with EHR systems.

KW - Clinical decision support

KW - Clinical information systems

KW - Genetics

KW - HL7

KW - Standards adoption

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JO - Applied clinical informatics

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ER -

Integrating genomic resources with electronic health records using the HL7 infobutton standard

Abstract

Keywords

ASJC Scopus subject areas

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