Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters

Leonardo X. Espín, Anders J. Asp, James K. Trevathan, Kip A. Ludwig, J. Luis Lujan

Research output: Contribution to journalArticlepeer-review


Modern techniques for estimating basal levels of electroactive neurotransmitters rely on the measurement of oxidative charges. This requires time integration of oxidation currents at certain intervals. Unfortunately, the selection of integration intervals relies on ad-hoc visual identification of peaks on the oxidation currents, which introduces sources of error and precludes the development of automated procedures necessary for analysis and quantification of neurotransmitter levels in large data sets. In an effort to improve charge quantification techniques, here we present novel methods for automatic selection of integration boundaries. Our results show that these methods allow quantification of oxidation reactions both in vitro and in vivo and of multiple analytes in vitro.

Original languageEnglish (US)
Article numbere0254594
JournalPloS one
Issue number7 July
StatePublished - Jul 2021

ASJC Scopus subject areas

  • General


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