Insights into the tumor microenvironment of B cell lymphoma

Wern Lynn Ng, Stephen M. Ansell, Patrizia Mondello

Research output: Contribution to journalReview articlepeer-review


The standard therapies in lymphoma have predominantly focused on targeting tumor cells with less of a focus on the tumor microenvironment (TME), which plays a critical role in favoring tumor growth and survival. Such an approach may result in increasingly refractory disease with progressively reduced responses to subsequent treatments. To overcome this hurdle, targeting the TME has emerged as a new therapeutic strategy. The TME consists of T and B lymphocytes, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and other components. Understanding the TME can lead to a comprehensive approach to managing lymphoma, resulting in therapeutic strategies that target not only cancer cells, but also the supportive environment and thereby ultimately improve survival of lymphoma patients. Here, we review the normal function of different components of the TME, the impact of their aberrant behavior in B cell lymphoma and the current TME-direct therapeutic avenues.

Original languageEnglish (US)
Article number362
JournalJournal of Experimental and Clinical Cancer Research
Issue number1
StatePublished - Dec 2022


  • B-cell lymphoma
  • Cancer-associated fibroblasts
  • Myeloid-derived suppressor cells
  • T cells
  • T follicular helper cells
  • T regulatory cells
  • Tumor microenvironment
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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