TY - JOUR
T1 - Injectable Biologics
T2 - What Is the Evidence?
AU - Kubrova, Eva
AU - D'Souza, Ryan S.
AU - Hunt, Christine L.
AU - Wang, Qian
AU - Van Wijnen, Andre J.
AU - Qu, Wenchun
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Injectable biologics have attracted considerable interest in the field of musculoskeletal medicine. Biologics encompass a broad and diverse group of human tissue-derived therapeutics. The most commonly reported biologics for use in musculoskeletal conditions include platelet-rich plasma, bone marrow aspirate concentrate, mesenchymal stem cells, microfragmented fat, stromal vascular fraction, amniotic membrane-based products, and autologous conditioned serum. The benefits of biologics in tissue healing and regeneration are thought to be derived from their trophic, paracrine, and immunomodulatory functions. The purpose of this review is to define commonly used injectable biologics and to appraise current evidence on its efficacy in the treatment of musculoskeletal disease.
AB - Injectable biologics have attracted considerable interest in the field of musculoskeletal medicine. Biologics encompass a broad and diverse group of human tissue-derived therapeutics. The most commonly reported biologics for use in musculoskeletal conditions include platelet-rich plasma, bone marrow aspirate concentrate, mesenchymal stem cells, microfragmented fat, stromal vascular fraction, amniotic membrane-based products, and autologous conditioned serum. The benefits of biologics in tissue healing and regeneration are thought to be derived from their trophic, paracrine, and immunomodulatory functions. The purpose of this review is to define commonly used injectable biologics and to appraise current evidence on its efficacy in the treatment of musculoskeletal disease.
KW - Biological Products
KW - Injectable
KW - Mesenchymal Stem Cells
KW - Osteoarthritis
KW - Platelet-Rich Plasma
KW - Tendinopathy
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U2 - 10.1097/PHM.0000000000001407
DO - 10.1097/PHM.0000000000001407
M3 - Review article
C2 - 32209835
AN - SCOPUS:85090960473
SN - 0894-9115
VL - 99
SP - 950
EP - 960
JO - American Journal of Physical Medicine and Rehabilitation
JF - American Journal of Physical Medicine and Rehabilitation
IS - 10
ER -