TY - JOUR
T1 - Initial treatment of patients with thyroid cancer
T2 - Outcomes and factors associated with care at academic versus nonacademic cancer centers
AU - Alhumaidi, Hebah
AU - Manochakian, Rami
AU - Cochuyt, Jordan
AU - Chindris, Ana
AU - Hodge, David
AU - Abdulazeez, Mays F.
AU - David, Shishir
AU - Biswas, Suman
AU - Aggarwal, Chander Shekher
AU - Smallridge, Robert C.
AU - Ailawadhi, Sikander
N1 - Publisher Copyright:
© 2020 American Cancer Society
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Background: Factors associated with receiving initial care for thyroid cancer (TC) at academic centers (ACs) versus nonacademic centers (NACs) and their impact on patient outcomes have not been reported. Methods: The National Cancer Database with TC cases from 2004 to 2013 was evaluated for association of type of center for initial care with socioeconomic factors and disease and treatment characteristics, as well as overall survival (OS; all-cause mortality). Results: The patients with TC (n = 200,824) included were predominantly women (74%), non-Hispanic Whites (85%), and from metro areas (84%). Sixty percent received initial care at a NAC. There were no significant differences between treatment groups by age or gender. Among those treated at an AC, a higher proportion belonged to racial/ethnic minorities (16.5%) versus at a NAC (11.6%). Hormone therapy was used more in an AC versus a NAC (60% vs 47%). Patients with all TC pathologies combined had a lower likelihood of death when they received initial care at an AC (hazard ratio [HR], 0.948; P =.0006). Among individual pathologic subtypes, a lower likelihood of death was noted when initial care was received at an AC for follicular (HR, 0.828, P =.0010) and Hurthle cell cancers (HR, 792; P =.0008), as well as stage II papillary thyroid cancer (HR, 0.828; P =.0026), but not for other histopathologic subtypes. Conclusions: Initial care at an AC was associated with lower likelihood of death for patients with TC, especially for those with follicular or Hurthle cell subtypes. Optimal resource use with consideration of patients' socioeconomic and demographic factors is imperative to ensure the most appropriate management of patients with TC in various treatment settings.
AB - Background: Factors associated with receiving initial care for thyroid cancer (TC) at academic centers (ACs) versus nonacademic centers (NACs) and their impact on patient outcomes have not been reported. Methods: The National Cancer Database with TC cases from 2004 to 2013 was evaluated for association of type of center for initial care with socioeconomic factors and disease and treatment characteristics, as well as overall survival (OS; all-cause mortality). Results: The patients with TC (n = 200,824) included were predominantly women (74%), non-Hispanic Whites (85%), and from metro areas (84%). Sixty percent received initial care at a NAC. There were no significant differences between treatment groups by age or gender. Among those treated at an AC, a higher proportion belonged to racial/ethnic minorities (16.5%) versus at a NAC (11.6%). Hormone therapy was used more in an AC versus a NAC (60% vs 47%). Patients with all TC pathologies combined had a lower likelihood of death when they received initial care at an AC (hazard ratio [HR], 0.948; P =.0006). Among individual pathologic subtypes, a lower likelihood of death was noted when initial care was received at an AC for follicular (HR, 0.828, P =.0010) and Hurthle cell cancers (HR, 792; P =.0008), as well as stage II papillary thyroid cancer (HR, 0.828; P =.0026), but not for other histopathologic subtypes. Conclusions: Initial care at an AC was associated with lower likelihood of death for patients with TC, especially for those with follicular or Hurthle cell subtypes. Optimal resource use with consideration of patients' socioeconomic and demographic factors is imperative to ensure the most appropriate management of patients with TC in various treatment settings.
KW - National Cancer Database
KW - academic center
KW - outcome disparities
KW - survival
KW - thyroid cancer
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U2 - 10.1002/cncr.33408
DO - 10.1002/cncr.33408
M3 - Article
C2 - 33449369
AN - SCOPUS:85099332687
SN - 0008-543X
VL - 127
SP - 1770
EP - 1778
JO - Cancer
JF - Cancer
IS - 11
ER -