Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome

Tiziano Barbui, Jürgen Thiele, Francesco Passamonti, Elisa Rumi, Emanuela Boveri, Maria Luigia Randi, Irene Bertozzi, Filippo Marino, Alessandro M. Vannucchi, Lisa Pieri, Giada Rotunno, Heinz Gisslinger, Bettina Gisslinger, Leonhard Müllauer, Guido Finazzi, Alessandra Carobbio, Andrea Gianatti, Marco Ruggeri, Ilaria Nichele, Emanuele D'AmoreAlessandro Rambaldi, Ayalew Tefferi

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibrosis. Presenting clinical and laboratory characteristics, including JAK2V617F allele burden, between patients with and without fibrosis were similar for the most part, with the exception of a higher prevalence of palpable splenomegaly in patients with fibrosis (P < .01). Patients with fibrosis were less prone to experience thrombosis during their clinical course (1.1 vs 2.7 per 100 patient-years; P = .03) and more prone to develop post-polycythemia vera myelofibrosis (2.2 vs 0.8 per 100 patient-years; P = .01). There was no significant difference between the 2 groups in terms of overall or leukemia-free survival. The present study clarifies the incidence, degree, and prognostic relevance of bone marrow fibrosis obtained at time of initial diagnosis of polycythemia vera.

Original languageEnglish (US)
Pages (from-to)2239-2241
Number of pages3
Issue number10
StatePublished - Mar 8 2012

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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