Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome

Medicine & Life Sciences

• (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol 100%
• TOR Serine-Threonine Kinases 59%
• Autophagy 51%
• Phosphotransferases 41%
• Cell Death 40%
• Down-Regulation 37%
• Drug Therapy 31%
• Mechanistic Target of Rapamycin Complex 2 17%
• Beclin-1 15%
• Mechanistic Target of Rapamycin Complex 1 14%
• Sequestosome-1 Protein 10%
• DNA Damage 10%
• Small Interfering RNA 9%
• Raptors 9%
• Phosphorylation 8%
• Multiprotein Complexes 7%
• S 6 7%
• 70-kDa Ribosomal Protein S6 Kinases 7%
• Cytoprotection 7%
• Chloroquine 6%
• Ectopic Gene Expression 6%
• Cell Cycle 4%
• Adenosine Triphosphate 4%

Chemical Compounds

• Cell Death 57%
• Cytoprotective 21%
• Clonogenic 11%
• Small Interfering RNA 10%
• Chloroquine 9%
• Silencing RNA 9%
• Protein 3%