Inhibition of 5 ‐ fluorouracil‐induced ocular irritation by ocular ice packs

Charles L. Loprinzi, Donald B. Wender, Michael H. Veeder, Judith R. O'Fallon, Nancy L. Vaught, Ann Marie Dose, Chirantan Ghosh, Joan Bartel, John M. Leitch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background. This clinical trial was developed to determine whether ocular ice pack therapy would decrease 5‐fluorouracil(5‐FU)‐induced ocular toxicity. Methods. Sixty‐two patients who suffered from 5‐FU‐induced ocular toxicity, and were scheduled to receive another cycle of the chemotherapy that caused the ocular toxicity, were entered in this clinical trial. A randomized, crossover design was used, with patients documenting their ocular toxicity by the use of daily diaries. Results. The results from the first cycle of treatment suggested that ocular ice pack therapy decreased 5‐FU‐induced ocular toxicity ( P = 0.056). The 38 evaluable patients in the crossover analyses demonstrated decreased ocular toxicity with ocular ice pack therapy (p = .001). The ocular ice pack therapy was well tolerated by most of the study participants. Conclusion. Ocular ice pack therapy appears to lessen 5‐FU‐induced ocular toxicity to a clinically moderate degree. Better methods for decreasing 5‐FU‐induced ocular toxicity are necessary.

Original languageEnglish (US)
Pages (from-to)945-948
Number of pages4
Issue number3
StatePublished - Aug 1 1994


  • 5‐fluorouracil‐induced conjunctivitis
  • 5‐fluorouracil‐induced ocular toxicity
  • ocular ice packs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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