Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia

Kevin L. Webb; Paolo B. Dominelli; Sarah E. Baker; Stephen A. Klassen; Michael J. Joyner; Jonathon W. Senefeld; Chad C. Wiggins

doi:10.3389/fphys.2021.763933

Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia

Kevin L. Webb, Paolo B. Dominelli, Sarah E. Baker, Stephen A. Klassen, Michael J. Joyner, Jonathon W. Senefeld, Chad C. Wiggins

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

Abstract

Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O₂) affinity. However, high Hb-O₂ affinity has been identified as a beneficial adaptation in several species that have been exposed to high altitude for generations. The observed differences in Hb-O₂ affinity between humans and species adapted to high altitude pose a central question: is higher or lower Hb-O₂ affinity in humans more advantageous when O₂ availability is limited? Humans with genetic mutations in hemoglobin structure resulting in high Hb-O₂ affinity have shown attenuated cardiorespiratory adjustments during hypoxia both at rest and during exercise, providing unique insight into this central question. Therefore, the purpose of this review is to examine the influence of high Hb-O₂ affinity during hypoxia through comparison of cardiovascular and respiratory adjustments elicited by humans with high Hb-O₂ affinity compared to those with normal Hb-O₂ affinity.

Original language	English (US)
Article number	763933
Journal	Frontiers in Physiology
Volume	12
DOIs	https://doi.org/10.3389/fphys.2021.763933
State	Published - Jan 14 2022

Keywords

VO (maximal oxygen uptake)
altitude acclimatization
exercise
high affinity hemoglobin (Hb)
high-altitude
oxygen transport

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.3389/fphys.2021.763933

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@article{37232ca350634703878537b9175a8c23,

title = "Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia",

abstract = "Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in several species that have been exposed to high altitude for generations. The observed differences in Hb-O2 affinity between humans and species adapted to high altitude pose a central question: is higher or lower Hb-O2 affinity in humans more advantageous when O2 availability is limited? Humans with genetic mutations in hemoglobin structure resulting in high Hb-O2 affinity have shown attenuated cardiorespiratory adjustments during hypoxia both at rest and during exercise, providing unique insight into this central question. Therefore, the purpose of this review is to examine the influence of high Hb-O2 affinity during hypoxia through comparison of cardiovascular and respiratory adjustments elicited by humans with high Hb-O2 affinity compared to those with normal Hb-O2 affinity.",

keywords = "VO (maximal oxygen uptake), altitude acclimatization, exercise, high affinity hemoglobin (Hb), high-altitude, oxygen transport",

author = "Webb, {Kevin L.} and Dominelli, {Paolo B.} and Baker, {Sarah E.} and Klassen, {Stephen A.} and Joyner, {Michael J.} and Senefeld, {Jonathon W.} and Wiggins, {Chad C.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Webb, Dominelli, Baker, Klassen, Joyner, Senefeld and Wiggins.",

year = "2022",

month = jan,

day = "14",

doi = "10.3389/fphys.2021.763933",

language = "English (US)",

volume = "12",

journal = "Frontiers in Physiology",

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TY - JOUR

T1 - Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia

AU - Webb, Kevin L.

AU - Dominelli, Paolo B.

AU - Baker, Sarah E.

AU - Klassen, Stephen A.

AU - Joyner, Michael J.

AU - Senefeld, Jonathon W.

AU - Wiggins, Chad C.

PY - 2022/1/14

Y1 - 2022/1/14

N2 - Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in several species that have been exposed to high altitude for generations. The observed differences in Hb-O2 affinity between humans and species adapted to high altitude pose a central question: is higher or lower Hb-O2 affinity in humans more advantageous when O2 availability is limited? Humans with genetic mutations in hemoglobin structure resulting in high Hb-O2 affinity have shown attenuated cardiorespiratory adjustments during hypoxia both at rest and during exercise, providing unique insight into this central question. Therefore, the purpose of this review is to examine the influence of high Hb-O2 affinity during hypoxia through comparison of cardiovascular and respiratory adjustments elicited by humans with high Hb-O2 affinity compared to those with normal Hb-O2 affinity.

AB - Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in several species that have been exposed to high altitude for generations. The observed differences in Hb-O2 affinity between humans and species adapted to high altitude pose a central question: is higher or lower Hb-O2 affinity in humans more advantageous when O2 availability is limited? Humans with genetic mutations in hemoglobin structure resulting in high Hb-O2 affinity have shown attenuated cardiorespiratory adjustments during hypoxia both at rest and during exercise, providing unique insight into this central question. Therefore, the purpose of this review is to examine the influence of high Hb-O2 affinity during hypoxia through comparison of cardiovascular and respiratory adjustments elicited by humans with high Hb-O2 affinity compared to those with normal Hb-O2 affinity.

KW - VO (maximal oxygen uptake)

KW - altitude acclimatization

KW - exercise

KW - high affinity hemoglobin (Hb)

KW - high-altitude

KW - oxygen transport

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U2 - 10.3389/fphys.2021.763933

DO - 10.3389/fphys.2021.763933

M3 - Review article

AN - SCOPUS:85123791775

SN - 1664-042X

VL - 12

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 763933

ER -

Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia

Abstract

Keywords

ASJC Scopus subject areas

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