Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort

Michelle M. Mielke, Mary M. Machulda, Clinton E. Hagen, Teresa J. Christianson, Rosebud O. Roberts, David S. Knopman, Prashanthi Vemuri, Val J. Lowe, Walter K. Kremers, Clifford R. Jack, Ronald C. Petersen

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Introduction Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals. Methods We included 464 cognitively normal, test-naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, mean age of 62.7 (range, 51-71 years), enrolled in the Mayo Clinic Study of Aging. Participants completed multiple cognitive assessments, including a standard neuropsychological battery and the CogState computerized battery, over 30 months of follow-up. Linear mixed models were used to examine the effects of amyloid and APOE genotype on baseline cognition and cognitive decline. Results Elevated amyloid was not associated with tests of episodic memory but did predict declines on tests of executive function. APOE genotype was not associated with cognition. Among APOE E ε4 noncarriers, higher amyloid was predictive of decline on tests of executive function and on one episodic memory test. Discussion Elevated amyloidosis and APOE genotype do not appear to exert a dramatic influence on cognition in middle age.

Original languageEnglish (US)
Pages (from-to)281-291
Number of pages11
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Mar 1 2016


  • APOE
  • Alzheimer's disease
  • Amyloid
  • Cognitive aging
  • Cohort studies
  • PET

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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