Inflammatory "cap" polyposis: A case report of a rare nonneoplastic colonic polyposis

Giovanni De Petris, Bal M. Dhungel, Longwen Chen, Shabana F. Pasha

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Inflammatory cap polyposis (ICP) is a rare nonneoplastic polyposis of the colon of unknown etiology that can be confused with prolapse-induced polyps and hyperplastic polyposis. We contribute a case of ICP from a 59-year-old woman who was affected by severe constipation and hematochezia. Numerous sessile and semipedunculated polyps were found in the colon, all with cap of whitish fibrin. Histology revealed erosion of the surface, superficial dilated crypts filled with mucoid inflammatory exudate, and minimal crypt serration, all findings typical of ICP. Only the largest polyps had smooth muscle in the mucosa. Ki-67 showed modest expansion and irregular distribution of the crypts proliferative areas. Lowdegree positivity for p16, similar to that of hyperplastic polyps, was found. CK20 was expressed as in normal mucosa. Distinguishing between ICP and other polyposis is important because of difference in management.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number4
StatePublished - Jun 2014


  • Constipation
  • Inflammatory cap polyposis
  • Serrated polyp

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine


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