Infectious endophthalmitis after intravitreal injection of antiangiogenic agents

Teresa Diago, Colin A. McCannel, Sophie J. Bakri, Jose S. Pulido, Albert O. Edwards, John M. Pach

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


PURPOSE: To evaluate the rate of infectious endophthalmitis associated with intravitreal injection of bevacizumab, ranibizumab, and pegaptanib sodium. METHODS: A retrospective review of patients who received intravitreal injections of bevacizumab, ranibizumab, and pegaptanib sodium was undertaken. Cases of clinical diagnoses of endophthalmitis or suspected endophthalmitis resulting from intravitreal injection were identified and reviewed. From these data, the risk per injection was estimated. RESULTS: Three patients developed endophthalmitis after the intravitreal injection. The risk per injection was 0.00077 (0.077%). The rate of endophthalmitis was 1 per 1,291 injections. CONCLUSION: A similar risk of endophthalmitis per injection compared with some trials was obtained in this study. Although no definite risk factors could be identified, intravitreal injections performed by nonretina specialist physicians may be a risk factor for the development of endophthalmitis.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
Issue number5
StatePublished - May 2009

ASJC Scopus subject areas

  • Ophthalmology


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