@inbook{2576148b3aa64d6b958e9bf1b17aaeef,
title = "Induction of pancreatic inflammation accelerates pancreatic tumorigenesis in mice",
abstract = "Pancreatitis is a major risk factor for the development of pancreatic cancer. In genetically engineered mouse models, induction of pancreatic inflammation dramatically accelerates oncogenic KRas-induced fibrosis, precancerous PanIN formation, and tumorigenesis. Here we describe simple methods of secretagogue-induced experimental acute and chronic pancreatitis, the most commonly used pancreatitis models, and their applications in pancreatic cancer research. Additionally, the preparation of primary pancreatic acinar cells is introduced. Primary acinar cells can be used to study the early events of pancreatic inflammation and pancreatic acinar-to-ductal (ADM) metaplasia.",
keywords = "Acinar cell, CCK, Caerulein, KRas, Pancreatic cancer, Pancreatitis",
author = "Lu Zhuang and Xianbao Zhan and Yan Bi and Baoan Ji",
note = "Funding Information: The work presented in this chapter was supported by Grant W81XWH-15-1-0257 from the US Department of Defense. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Defense. Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2019",
doi = "10.1007/978-1-4939-8879-2_25",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "287--297",
booktitle = "Methods in Molecular Biology",
}