Induction of multidrug resistance proteins MRP1 and MRP3 and γ-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells

Medicine & Life Sciences

• Sulindac 100%
• Glutamate-Cysteine Ligase 96%
• Subfamily B ATP Binding Cassette Transporter 96%
• multidrug resistance-associated protein 1 95%
• Colonic Neoplasms 61%
• Reactive Oxygen Species 54%
• Anti-Inflammatory Agents 49%
• Gene Expression 40%
• Acetylcysteine 38%
• Pharmaceutical Preparations 28%
• Colorectal Neoplasms 26%
• Carcinogenesis 25%
• Oxidative Stress 24%
• MDR Genes 23%
• Membrane Transport Proteins 20%
• Antineoplastic Agents 16%
• Drug Resistance 15%
• Glutathione 15%
• Genes 13%
• Antioxidants 12%
• Down-Regulation 11%
• Cell Line 10%
• Enzymes 9%

Chemical Compounds

• Sulindac 83%
• Nonsteroid Antiinflammatory Agent 78%
• Reactive Oxygen Metabolite 47%
• Resistance 42%
• Protein 28%
• Oxidative Stress 16%
• Glutathione 15%
• Antineoplastic Agent 15%
• Biosynthesis 14%
• Antioxidant Agent 12%
• Dioxygen 8%