Abstract
Angiogenesis, the formation of new capillary blood vessels, has been studied following the stereotaxic injection of β-amyloid peptide (Aβ1-42) into rat hippocampus. Immunohistochemical analysis for laminin showed that neovascularization was only slightly increased, relative to control, in the hippocampus 1 day post-Aβ1-42 injection. However, 7 days following peptide injection neovascularization was markedly up-regulated (by 2.2-fold) compared to control. Immunoreactivity for the angiogenic stimulatory agent vascular endothelial growth factor (VEGF) was also significantly increased in the hippocampus 7 days after Aβ1-42 injection. Double immunofluorescence staining demonstrated that the increased level of VEGF immunoreactivity was localized to both astrocytes and microglia, suggesting inflammatory responses contributed to angiogenesis. The findings of β-amyloid stimulated angiogenesis and the involvement of peptide-induced inflammatory processes may have relevance to the pathology of Alzheimer's disease.
Original language | English (US) |
---|---|
Pages (from-to) | 129-132 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Feb 8 2005 |
Keywords
- Alzheimer's disease β-Amyloid peptide
- Angiogenesis
- Astrocytes
- Inflammation
- Microglia
- VEGF
ASJC Scopus subject areas
- General Neuroscience