Induced pluripotent stem cells for the treatment of liver diseases: Novel concepts

Jia Yao, Yue Yu, Scott L. Nyberg

Research output: Contribution to journalReview articlepeer-review


Millions of people worldwide with incurable liver disease die because of inadequate treatment options and limited availability of donor organs for liver transplantation. Regenerative medicine as an innovative approach to repairing and replacing cells, tissues, and organs is undergoing a major revolution due to the unprecedented need for organs for patients around the world. Induced pluripotent stem cells (iPSCs) have been widely studied in the field of liver regeneration and are considered to be the most promising candidate therapies. This review will conclude the current state of efforts to derive human iPSCs for potential use in the modeling and treatment of liver disease.

Original languageEnglish (US)
Pages (from-to)368-382
Number of pages15
JournalCells Tissues Organs
Issue number4
StatePublished - 2020


  • Blastocyst complementation
  • Induced pluripotent stem cells
  • Liver diseases
  • Liver transplantation
  • Regeneration medicine

ASJC Scopus subject areas

  • Anatomy
  • Histology


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