TY - JOUR
T1 - Individualized Ablation of Hepatocellular Carcinoma
T2 - Tailored Approaches across the Phenotype Spectrum
AU - Devcic, Zlatko
AU - Elboraey, Mohamed
AU - Vidal, Lucas
AU - Mody, Kabir
AU - Harnois, Denise
AU - Patel, Tushar
AU - Toskich, Beau B.
N1 - Publisher Copyright:
© 2019 Massachussetts Medical Society. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Ablation is now recommended by international guidelines for the definitive treatment of hepatocellular carcinoma (HCC). Extensive clinical studies have demonstrated outcomes comparable to surgical resection with shorter hospital stays, decreased costs, and improved quality of life. Successful ablation requires complete treatment of both tumor and margin while preserving critical adjacent structures. HCC exhibits highly variable presentations in both anatomic involvement and biology which have significant implications on choice of ablative therapy. There are now abundant ablation modalities and adjunctive techniques which can be used to individualize ablation and maximize curative results. This article provides a patient-centered summary of approaches to HCC ablation in the context of patient performance, hepatic reserve, tumor phenotype and biology, intra- A nd extrahepatic anatomy, and ablation technology.
AB - Ablation is now recommended by international guidelines for the definitive treatment of hepatocellular carcinoma (HCC). Extensive clinical studies have demonstrated outcomes comparable to surgical resection with shorter hospital stays, decreased costs, and improved quality of life. Successful ablation requires complete treatment of both tumor and margin while preserving critical adjacent structures. HCC exhibits highly variable presentations in both anatomic involvement and biology which have significant implications on choice of ablative therapy. There are now abundant ablation modalities and adjunctive techniques which can be used to individualize ablation and maximize curative results. This article provides a patient-centered summary of approaches to HCC ablation in the context of patient performance, hepatic reserve, tumor phenotype and biology, intra- A nd extrahepatic anatomy, and ablation technology.
KW - ablation
KW - hepatocellular carcinoma
KW - locoregional therapy
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U2 - 10.1055/s-0039-1698755
DO - 10.1055/s-0039-1698755
M3 - Article
AN - SCOPUS:85074705784
SN - 0739-9529
VL - 36
SP - 287
EP - 297
JO - Seminars in Interventional Radiology
JF - Seminars in Interventional Radiology
IS - 4
ER -