Individual predisposition to coronary microvascular obstruction

R. Jay Widmer, Amir Lerman

Research output: Chapter in Book/Report/Conference proceedingChapter


Coronary microvascular obstruction (CMVO) during ST-elevation myocardial infarction can occur in up to half of those presenting to the cardiac catheterization laboratory and undergo percutaneous revascularization. Poor microvascular and endothelial function are known to be associated with CMVO, and are potential avenues for preventative strategies. In this chapter, we highlight the associations between poor microvascular and endothelial function, provide clinical signs and manifestations of poor systemic endothelial and/or microvascular function, and outline some strategies to prevent endothelial and microvascular function.

Original languageEnglish (US)
Title of host publicationCoronary Microvascular Obstruction in Acute Myocardial Infarction
Subtitle of host publicationFrom Mechanisms to Treatment
Number of pages13
ISBN (Electronic)9780128125281
ISBN (Print)9780128133613
StatePublished - Jan 1 2018


  • Endothelial dysfunction
  • Microcirculation
  • Prevention

ASJC Scopus subject areas

  • General Medicine


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