Increased Prevalence of Metabolic Risk Factors in Asian Americans with Hepatocellular Carcinoma

Alina Kutsenko, Maya R. Ladenheim, Nathan Kim, Pauline Nguyen, Vincent Chen, Channa Jayasekera, Ju Dong Yang, Radhika Kumari, Lewis Roberts, Mindie H. Nguyen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: We used metabolic risk factors to estimate the prevalence and clinical significance of nonalcoholic fatty liver disease in Asian Americans with hepatocellular carcinoma (HCC). Methods: This is a retrospective cohort study of 824 consecutive Asian HCC patients at Stanford University Medical Center from 1998 to 2015. Patients were subdivided as: Chinese, other East Asian (Japanese and Korean), South East Asian (Vietnamese, Thai, and Laotian), Maritime South East Asian (MSEA: Malaysian, Indonesian, Filipino, and Singaporean), and South West Asian (Indian, Pakistani, and Middle Eastern). Metabolic risk factors studied were body mass index, hypertension, type II diabetes, and hyperlipidemia. Results: Most patients were male (76%) with mean age 63 years. Metabolic risk factors were highly prevalent on presentation and increased over time (P<0.001), as did the prevalence of cryptogenic HCC (P<0.004). Compared with other Asian subgroups, MSEAs had the highest body mass index (26.3) and higher rates of type II diabetes (44% vs. 23% to 35%, P=0.004), hypertension (59% vs. 38% to 55%, P=0.04), and cryptogenic HCC (15% vs. 4% to 10%, P=0.01). They were more likely to be symptomatic on presentation (44% vs. 32% to 58%, P=0.07), less likely to present within Milan criteria (34% vs. 35% to 63%, P<0.0001), and trended toward decreased 10-year survival rates compared with other ethnic subgroups (9% vs. 25% to 32%, P=0.07). Conclusions: Metabolic risk factors were increasingly prevalent among Asian Americans with HCC. MSEAs, who had the highest incidence of these risk factors, had more advanced tumor stage and trended toward worse survival.

Original languageEnglish (US)
Pages (from-to)384-390
Number of pages7
JournalJournal of clinical gastroenterology
Issue number4
StatePublished - 2017


  • Asian Americans
  • HCC
  • ethnicity
  • metabolic syndrome

ASJC Scopus subject areas

  • Gastroenterology


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