Abstract
Collagenous sprue is a rare enteropathy whose etiology is unknown, but immune-mediated mechanisms are one of several possibilities. However, the role of immunoglobulin G4 (IgG4)-positive plasma cells has not been studied in collagenous sprue. Endoscopic biopsies from the duodenum with a histologic diagnosis of collagenous sprue (n = 40 from 35 patients), celiac disease (n = 25), peptic duodenitis (n = 15) and normal duodenum (n = 25) were immunohistochemically stained with IgG4 and CD138 antibodies. For each case, the quantities of IgG4- and CD138-positive plasma cells in the lamina propria were estimated by averaging the number in 3 high-power fields (hpf) that showed the highest concentration. Nine of forty collagenous sprue samples showed a mean of 10 or more IgG4 plasma cells per hpf, whereas none of the duodenal control biopsies showed 10 or more IgG4 plasma cells per hpf: celiac disease (P =.01), peptic duodenitis (P =.05), and normal duodenum (P =.01). Our study demonstrates that increased IgG4-positive plasma cells are present in a subset (23%) of collagenous sprue and may play a role in its pathogenesis.
Original language | English (US) |
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Pages (from-to) | 1624-1629 |
Number of pages | 6 |
Journal | Human Pathology |
Volume | 44 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2013 |
Keywords
- Collagenous sprue
- Duodenum
- IgG4
- Plasma cells
ASJC Scopus subject areas
- Pathology and Forensic Medicine