Increased immunoglobulin G4-positive plasma cells in collagenous sprue

J. Kenneth Schoolmeester, Sarah M. Jenkins, Joseph A. Murray, Tsung Teh Wu, Vishal S. Chandan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Collagenous sprue is a rare enteropathy whose etiology is unknown, but immune-mediated mechanisms are one of several possibilities. However, the role of immunoglobulin G4 (IgG4)-positive plasma cells has not been studied in collagenous sprue. Endoscopic biopsies from the duodenum with a histologic diagnosis of collagenous sprue (n = 40 from 35 patients), celiac disease (n = 25), peptic duodenitis (n = 15) and normal duodenum (n = 25) were immunohistochemically stained with IgG4 and CD138 antibodies. For each case, the quantities of IgG4- and CD138-positive plasma cells in the lamina propria were estimated by averaging the number in 3 high-power fields (hpf) that showed the highest concentration. Nine of forty collagenous sprue samples showed a mean of 10 or more IgG4 plasma cells per hpf, whereas none of the duodenal control biopsies showed 10 or more IgG4 plasma cells per hpf: celiac disease (P =.01), peptic duodenitis (P =.05), and normal duodenum (P =.01). Our study demonstrates that increased IgG4-positive plasma cells are present in a subset (23%) of collagenous sprue and may play a role in its pathogenesis.

Original languageEnglish (US)
Pages (from-to)1624-1629
Number of pages6
JournalHuman Pathology
Issue number8
StatePublished - Aug 2013


  • Collagenous sprue
  • Duodenum
  • IgG4
  • Plasma cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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