Increased cardio-ankle vascular index in hyperlipidemic patients without diabetes or hypertension

Petr Dobsak, Vladimir Soska, Ondrej Sochor, Jiri Jarkovsky, Marie Novakova, Martin Homolka, Miroslav Soucek, Petra Palanova, Francisco Lopez-Jimenez, Kohji Shirai

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Aim: The cardio-ankle vascular index (CAVI) is a sensitive non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to compare the CAVI values in patients with dyslipidemia (without diabetes mellitus and hypertension) and healthy controls. Methods: A Total 248 subjects with dyslipidemia (104 men, 144 women), 55.0 (95% CI 30-70) years of age with combined hyperlipidemia or primary hypercholesterolemia and 537 healthy controls (244 men, 293 women) 40.0 (95% CI 26-62) years of age were included in this study. Fasting blood samples were collected to measure the serum total cholesterol, triglyceride, HDL-cholesterol and apolipoprotein A1 and B levels. The LDL cholesterol level was also calculated, and the CAVI was measured using the VaSera® 1500 system. Results: The CAVI values were significantly higher in the dyslipidemic patients (8.08, 95% CI 6.00- 10.05) than in the controls (7.11, 95% CI 5.77-9.05; p<0.01). In addition, the CAVI values were elevated in both subgroups of patients with hypercholesterolemia (7.95, 95% CI 5.85-6.90; p<0.01) and combined hyperlipidemia (8.30, 95% CI 6.60-10.15; p<0.01) in comparison with those observed in the controls. After adopting the propensity score method in order to balance the confounding factors (age, gender, body mass index) and adjust the analysis for diastolic blood pressure, the CAVI values in the dyslipidemic patients remained significantly high (7.78, 95% CI 5.80-9.69) compared to that observed in the controls (7.31, 95% CI 5.44-9.35; p<0.001). However, the CAVI values did not differ significantly between the controls and both subgroups of dyslipidemic patients (primary hypercholesterolemia, combined hyperlipidemia). Conclusions: The present findings demonstrated that dyslipidemia increases the CAVI values in comparison to that seen in healthy subjects.

Original languageEnglish (US)
Pages (from-to)272-283
Number of pages12
JournalJournal of Atherosclerosis and Thrombosis
Issue number3
StatePublished - Nov 18 2015


  • Cardio-ankle vascular index
  • Combined hyperlipidemia
  • Hypercholesterolemia

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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