Incidence of frontotemporal disorders in Olmsted County: A population-based study

Pierpaolo Turcano, Cole D. Stang, Michelle M. Mielke, Peter R. Martin, Sudhindra G. Upadhyaya, Keith A. Josephs, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Rodolfo Savica

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P <.001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.

Original languageEnglish (US)
Pages (from-to)482-490
Number of pages9
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Mar 1 2020


  • Behavioral variant frontotemporal dementia
  • Frontotemporal-dementia disorders (FTDs)
  • Incidence
  • Neurodegenerative dementia
  • Population-based cohort

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


Dive into the research topics of 'Incidence of frontotemporal disorders in Olmsted County: A population-based study'. Together they form a unique fingerprint.

Cite this