Incidence of bleeding complications after percutaneous core needle biopsy in hypertensive patients and comparison to normotensive patients

Theodora A. Potretzke, Tina M. Gunderson, David Aamodt, Adam J. Weisbrod, Gina K. Hesley, Timothy J. Welch, Thomas D. Atwell

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose: To retrospectively determine the rate of major bleeding complications after solid organ or lung biopsy in patients with hypertension and compare to the rates of bleeding in normotensive patients. Materials and methods: Following IRB approval, retrospective review of all solid organ and lung biopsies performed at our institution between June 1st, 2013 and October 31st, 2015 was performed. Hypertension was defined as a maximum observed systolic blood pressure of 160 mmHg or greater and/or diastolic blood pressure of 90 mmHg or greater at the time of the biopsy procedure. Bleeding complications were defined using the Common Terminology Criteria for Adverse Events (CTCAE, version 4.0) established by the National Cancer Institute. Results: 4756 total biopsies in 3876 unique patients (median age 60, 57% male) were included. 1488 (31.3%) of these biopsies were performed in hypertensive patients. Fifteen major hemorrhages (CTCAE grade 3 or higher) occurred (0.32%). There were no deaths. There was no significant association between hypertension and major bleeding. The incidence of bleeding in hypertensive patients was 0.40% (6/1488), which was not statistically different than the incidence in normotensive patients (9/3268, 0.28%, p = 0.496). For the subgroup of native renal parenchymal biopsies, the rate of bleeding was slightly higher in hypertensive patients (3/213, 1.4% vs. 1/355, 0.28% in normotensive patients) but remained low, and the difference was not statistically significant (p = 0.188). Conclusion: The overall incidence of major bleeding after percutaneous biopsy is very low. Hypertension does not appear to significantly increase the risk of major bleeding complications.

Original languageEnglish (US)
Pages (from-to)637-642
Number of pages6
JournalAbdominal Radiology
Issue number4
StatePublished - Apr 1 2016


  • Biopsy
  • Bleeding
  • Computed tomography
  • Hypertension
  • Ultrasound

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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