Incidence and Burden of Tricuspid Regurgitation in Patients With Atrial Fibrillation

Sri Harsha Patlolla, Hartzell V. Schaff, Rick A. Nishimura, John M. Stulak, Alanna M. Chamberlain, Sorin V. Pislaru, Vuyisile T. Nkomo

Research output: Contribution to journalArticlepeer-review


Background: Atrial fibrillation (AF) is considered a risk factor for isolated tricuspid valve regurgitation (TR) in the absence of other known etiologies. Objectives: This study sought to identify the incidence of clinically significant isolated TR and its impact in patients with AF. Methods: A population-based record linkage system was used to identify adult patients with new-onset AF. Patients with evidence of moderate or greater tricuspid valve disease, left-sided valve disease, pulmonary hypertension, prior cardiac surgery, impaired left ventricular systolic/diastolic function at baseline were excluded. The remaining patients (n = 691) were followed over time to identify development of moderate or greater TR and assess its impact on subsequent survival. Results: A total of 232 patients (33.6%) developed moderate or greater TR. Among these, 73 patients (10.6%) had isolated TR without significant underlying structural heart disease. Incidence rate of any moderate or greater TR was 3.9 cases and that of isolated TR was 1.3 cases per 100 person-years. Permanent/persistent AF and female sex were associated with increased risk of developing TR, whereas rhythm control was associated with lower risk of TR. Over a median clinical follow-up of 13.3 years (IQR: 10.0-15.9 years), development of any moderate or greater TR (HR: 2.92; 95% CI: 2.29-3.73; P < 0.001) and isolated significant TR (HR: 1.51; 95% CI: 1.03-2.22; P = 0.03) were associated with an adjusted increased risk of subsequent mortality. Conclusions: In this population-based cohort of patients with AF, nearly one-third developed moderate or greater TR over time. Incident significant TR and incident isolated significant TR portend a worse survival in patients with AF.

Original languageEnglish (US)
Pages (from-to)2289-2298
Number of pages10
JournalJournal of the American College of Cardiology
Issue number24
StatePublished - Dec 13 2022


  • atrial fibrillation
  • incidence
  • population-based
  • survival
  • tricuspid valve regurgitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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