TY - JOUR
T1 - Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection
AU - Block, Matthew S.
AU - Mendez-Fernandez, Yanice V.
AU - Van Keulen, Virginia P.
AU - Hansen, Michael J.
AU - Allen, Kathleen S.
AU - Taboas, Anya L.
AU - Rodriguez, Moses
AU - Pease, Larry R.
PY - 2005/3/1
Y1 - 2005/3/1
N2 - Natural selection drives diversification of MHC class I proteins, but the mechanism by which selection for polymorphism occurs is not known. New variant class I alleles differ from parental alleles both in the nature of the CD8 T cell repertoire formed and the ability to present pathogen-derived peptides. In the current study, we examined whether T cell repertoire differences, Ag presentation differences, or both account for differential viral resistance between mice bearing variant and parental alleles. We demonstrate that nonresponsive mice have inadequate presentation of viral Ag, but have T cell repertoires capable of mounting Ag-specific responses. Although previous work suggests a correlation between the ability to present an Ag and the ability to generate a repertoire responsive to that Ag, we show that the two functions of MHC class I are independent.
AB - Natural selection drives diversification of MHC class I proteins, but the mechanism by which selection for polymorphism occurs is not known. New variant class I alleles differ from parental alleles both in the nature of the CD8 T cell repertoire formed and the ability to present pathogen-derived peptides. In the current study, we examined whether T cell repertoire differences, Ag presentation differences, or both account for differential viral resistance between mice bearing variant and parental alleles. We demonstrate that nonresponsive mice have inadequate presentation of viral Ag, but have T cell repertoires capable of mounting Ag-specific responses. Although previous work suggests a correlation between the ability to present an Ag and the ability to generate a repertoire responsive to that Ag, we show that the two functions of MHC class I are independent.
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U2 - 10.4049/jimmunol.174.5.2756
DO - 10.4049/jimmunol.174.5.2756
M3 - Article
C2 - 15728484
AN - SCOPUS:14044250865
SN - 0022-1767
VL - 174
SP - 2756
EP - 2762
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -