@inbook{9998ee044b0540af985445404825c4b0,
title = "In vivo magnetic resonance imaging techniques for structural and functional characterization of murine model kidneys",
abstract = "Murine models are used in a wide range of renal studies, from those assessing the role of molecular and genetic factors in mammalian development and congenital diseases, to developing and screening new therapeutics. In studies of these models, magnetic resonance imaging (MRI) techniques are playing an ever increasing role in characterizing both structural and functional changes of the kidneys. This chapter details the use of MRI for this purpose—from acquisition to image analysis. An overview of the wide range of characterization that can be performed by this technology is first given. Next, basic image analysis and more advanced image processing techniques are detailed. The utility of MR for characterizing anatomical and physiological properties of murine models of disease is supplemented with data from our work studying polycystic kidney disease.",
keywords = "Imaging biomarkers, Multiparametric MR, Murine model systems, Polycystic kidney disease, Quantitative MR, Renal imaging, Texture analysis, Total kidney volume",
author = "Kline, {Timothy Lee}",
note = "Funding Information: The author would like to thank Ms. Megan C. Constans and Ms. Sigapriya Periyanan for their help with MR image acquisitions, and Drs. Slobodan I. Macura, Lilach O. Lerman, and Kai Jiang for help with MR imaging protocols. Also thanks to Dr. Federico Franchi for his preparation of the micro-CT example, and Mr. Andrew J. Vercnocke and Ms. Mahya Sheikhzadeh for their help acquiring the micro-CT image. In addition, the author would like to thank Ms. Marie. E. Edwards and Andrew J. Metzger for their help with image analysis. Lastly, the author is grateful to Drs. Bradley J. Erickson, Peter C. Harris, and Vicente E. Torres for their mentorship in radiological imaging, genetics, and polycystic kidney disease. Data reported in this chapter was supported in part by the Mayo Clinic Robert M. and Billie Kelley Pirnie Translational PKD Center and the NIDDK grants P30DK090728 and K01DK110136. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
doi = "10.1016/bs.mcb.2019.05.007",
language = "English (US)",
isbn = "9780128203354",
series = "Methods in Cell Biology",
publisher = "Academic Press Inc",
pages = "145--161",
editor = "Thomas Weimbs",
booktitle = "Methods in Kidney Cell Biology - Part B",
}