TY - JOUR
T1 - In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction
T2 - An animal study
AU - Soreide, E.
AU - Denbeigh, J. M.
AU - Thaler, R.
AU - Yao, J. J.
AU - van Wijnen, A. J.
AU - Kakar, S.
AU - Lewallen, E. A.
AU - Xu, W.
AU - Berglund, L.
AU - Martinez, A.
AU - Nordsletten, L.
N1 - Funding Information:
This work was supported in part by The Research Council of Norway 239871/ F20 (ES). Additionally, research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01 AR049069 (AvW) and F32 AR068154 (EAL). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Although none of the authors has received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article, benefits have been or will be received but will be directed solely to a research fund, foundation, educational institution, or other non- profit organization with which one or more of the authors are associated. The authors would like to thank Chenghao Zhang and Will H. Trousdale for technical assistance, and members of the van Wijnen laboratory for valuable contributions of expertise and input in our discussions. We thank Phillip Edwards at the Bioimaging Resource Core and Teresa Decklever at the Nuclear Medicine Molecular Imaging Resource at Mayo Clinic for assistance with µCT image analysis. James Herrick and Robert Brown facilitated histological assessment. Steve Krage, Joanne Pedersen, and Mary Nagel provided excellent assistance with animal handling and care. We express our appreciation to Kristin Mara and Dirk Larson for statistical assistance.
Funding Information:
This work was supported in part by The Research Council of Norway 239871/ F20 (ES). Additionally, research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01 AR049069 (AvW) and F32 AR068154 (EAL). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
©2019 The British Editorial Society of Bone & Joint Surgery.
PY - 2019/10
Y1 - 2019/10
N2 - Options for the treatment of intra-articular ligament injuries are limited, and insufficient ligament reconstruction can cause painful joint instability, loss of function, and progressive development of degenerative arthritis. This study aimed to assess the capability of a biologically enhanced matrix material for ligament reconstruction to withstand tensile forces within the joint and enhance ligament regeneration needed to regain joint function. Materials and Methods A total of 18 New Zealand rabbits underwent bilateral anterior cruciate ligament reconstruction by autograft, FiberTape, or FiberTape-augmented autograft. Primary outcomes were biomechanical assessment (n = 17), microCT (µCT) assessment (n = 12), histological evaluation (n = 12), and quantitative polymerase chain reaction (qPCR) analysis (n = 6). Results At eight weeks, FiberTape alone or FiberTape-augmented autograft demonstrated increased biomechanical stability compared with autograft regarding ultimate load to failure (p = 0.035), elongation (p = 0.006), and energy absorption (p = 0.022). FiberTape-grafted samples also demonstrated increased bone mineral density in the bone tunnel (p = 0.039). Histological evaluation showed integration of all grafts in the bone tunnels by new bone formation, and limited signs of inflammation overall. A lack of prolonged inflammation in all samples was confirmed by quantification of inflammation biomarkers. However, no regeneration of ligament-like tissue was observed along the suture tape materials. Except for one autograft failure, no adverse events were detected. Conclusion Our results indicate that FiberTape increases the biomechanical performance of intraarticular ligament reconstructions in a verified rabbit model at eight weeks. Within this period, FiberTape did not adversely affect bone tunnel healing or invoke a prolonged elevation in inflammation.
AB - Options for the treatment of intra-articular ligament injuries are limited, and insufficient ligament reconstruction can cause painful joint instability, loss of function, and progressive development of degenerative arthritis. This study aimed to assess the capability of a biologically enhanced matrix material for ligament reconstruction to withstand tensile forces within the joint and enhance ligament regeneration needed to regain joint function. Materials and Methods A total of 18 New Zealand rabbits underwent bilateral anterior cruciate ligament reconstruction by autograft, FiberTape, or FiberTape-augmented autograft. Primary outcomes were biomechanical assessment (n = 17), microCT (µCT) assessment (n = 12), histological evaluation (n = 12), and quantitative polymerase chain reaction (qPCR) analysis (n = 6). Results At eight weeks, FiberTape alone or FiberTape-augmented autograft demonstrated increased biomechanical stability compared with autograft regarding ultimate load to failure (p = 0.035), elongation (p = 0.006), and energy absorption (p = 0.022). FiberTape-grafted samples also demonstrated increased bone mineral density in the bone tunnel (p = 0.039). Histological evaluation showed integration of all grafts in the bone tunnels by new bone formation, and limited signs of inflammation overall. A lack of prolonged inflammation in all samples was confirmed by quantification of inflammation biomarkers. However, no regeneration of ligament-like tissue was observed along the suture tape materials. Except for one autograft failure, no adverse events were detected. Conclusion Our results indicate that FiberTape increases the biomechanical performance of intraarticular ligament reconstructions in a verified rabbit model at eight weeks. Within this period, FiberTape did not adversely affect bone tunnel healing or invoke a prolonged elevation in inflammation.
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U2 - 10.1302/0301-620X.101B10.BJJ-2018-1282.R2
DO - 10.1302/0301-620X.101B10.BJJ-2018-1282.R2
M3 - Article
C2 - 31564153
AN - SCOPUS:85072745895
SN - 2049-4394
VL - 101-B
SP - 1238
EP - 1247
JO - Bone and Joint Journal
JF - Bone and Joint Journal
IS - 10
ER -