In vitro activity of oritavancin against planktonic and biofilm states of vancomycin-susceptible and vancomycin-resistant enterococci

Qun Yan; Melissa J. Karau; Robin Patel

doi:10.1016/j.diagmicrobio.2018.03.008

In vitro activity of oritavancin against planktonic and biofilm states of vancomycin-susceptible and vancomycin-resistant enterococci

Qun Yan, Melissa J. Karau, Robin Patel

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.

Original language	English (US)
Journal	Diagnostic Microbiology and Infectious Disease
DOIs	https://doi.org/10.1016/j.diagmicrobio.2018.03.008
State	Accepted/In press - Jan 1 2018

Keywords

Biofilm
Enterococcus faecalis
Enterococcus faecium
Oritavancin
VRE

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2018.03.008

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title = "In vitro activity of oritavancin against planktonic and biofilm states of vancomycin-susceptible and vancomycin-resistant enterococci",

abstract = "We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.",

keywords = "Biofilm, Enterococcus faecalis, Enterococcus faecium, Oritavancin, VRE",

author = "Qun Yan and Karau, {Melissa J.} and Robin Patel",

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AU - Yan, Qun

AU - Karau, Melissa J.

AU - Patel, Robin

PY - 2018/1/1

Y1 - 2018/1/1

N2 - We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.

AB - We tested the in vitro activity of oritavancin against 60 vancomycin-susceptible enterococci (VSE) and 27 vancomycin-resistant enterococci (VRE). The oritavancin MIC ranged from ≤0.002 to 0.5 μg/mL; the minimum biofilm bactericidal concentration ranged from ≤0.002 to 2 μg/mL. Oritavancin has promising in vitro activity against VSE and VRE in both planktonic and biofilm states.

KW - Biofilm

KW - Enterococcus faecalis

KW - Enterococcus faecium

KW - Oritavancin

KW - VRE

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JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

ER -

In vitro activity of oritavancin against planktonic and biofilm states of vancomycin-susceptible and vancomycin-resistant enterococci

Abstract

Keywords

ASJC Scopus subject areas

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