In-hospital outcomes associated with stent-assisted endovascular treatment of unruptured cerebral aneurysms in the USA

Jennifer S. McDonald, Andrew P. Norgan, Robert J. McDonald, Lanzino Giuseppe Lanzino, David F. Kallmes, Harry J. Cloft

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background Adjunctive stenting has increasingly become an acceptable option for the endovascular treatment of unruptured aneurysms. The Nationwide Inpatient Sample (NIS) was used to compare US inhospital outcomes related to coiling with and without adjunctive stenting for unruptured aneurysms. Methods Hospitalizations for coiling of unruptured cerebral aneurysms from 2004 to 2008 were identified in the NIS by extracting ICD-9-CM codes for the diagnosis of unruptured aneurysm (437.3) and intracranial stenting (00.65) with coiling (39.52, 39.79 or 39.72) of cerebral aneurysms. All patients with a diagnosis of subarachnoid hemorrhage (430) and/or intracerebral hemorrhage (431) were excluded. Mortality and discharge to a long-term facility were compared between stent and non-stent patient groups using multivariate regression analysis. Results Patients treated with stent-assisted coiling had an in-hospital mortality rate of 0.08-0.8% compared with a death rate of 0.5% (95% CI 0.3% to 0.7%) for patients who did not receive a stent during coiling (p=0.36). Patients in the stent group had a 3% rate of discharge to a care facility (95% CI 1.5% to 5.8%) compared with 5% (95% CI 4.5% to 5.6%) for those in the non-stent group (p=0.14). Patients treated with a stent had a similar likelihood of in-hospital mortality (adjusted OR, 2.12 (95% CI 0.32 to 7.11), p=0.34) and a lower likelihood of discharge to a long-term care facility (adjusted OR 0.59 (95% CI 0.24 to 1.16), p=0.16) compared with the non-stent group. Conclusions Adjunctive stenting adds little in-hospital risk to the endovascular treatment of cerebral aneurysms. However, the need for dual antiplatelet therapy may predispose to delayed hemorrhagic complications and discontinuation of dual antiplatelet therapy may lead to delayed thromboembolic complications.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalJournal of neurointerventional surgery
Issue number4
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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