Improvement of Shear Wave Motion Detection Using Harmonic Imaging in Healthy Human Liver

Carolina Amador, Pengfei Song, Duane D. Meixner, Shigao Chen, Matthew W. Urban

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Quantification of liver elasticity is a major application of shear wave elasticity imaging (SWEI) to non-invasive assessment of liver fibrosis stages. SWEI measurements can be highly affected by ultrasound image quality. Ultrasound harmonic imaging has exhibited a significant improvement in ultrasound image quality as well as for SWEI measurements. This was previously illustrated in cardiac SWEI. The purpose of this study was to evaluate liver shear wave particle displacement detection and shear wave velocity (SWV) measurements with fundamental and filter-based harmonic ultrasound imaging. In a cohort of 17 patients with no history of liver disease, a 2.9-fold increase in maximum shear wave displacement, a 0.11 m/s decrease in the overall interquartile range and median SWV and a 17.6% increase in the success rate of SWV measurements were obtained when filter-based harmonic imaging was used instead of fundamental imaging.

Original languageEnglish (US)
Pages (from-to)1031-1041
Number of pages11
JournalUltrasound in Medicine and Biology
Issue number5
StatePublished - May 1 2016


  • Filter-based harmonic imaging
  • In vivo
  • Liver elasticity
  • Shear wave elasticity imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


Dive into the research topics of 'Improvement of Shear Wave Motion Detection Using Harmonic Imaging in Healthy Human Liver'. Together they form a unique fingerprint.

Cite this