TY - JOUR
T1 - Implications of Tumor Surgery in Horseshoe Kidneys
T2 - A Comparative Study of Outcomes and Surgical Practices
AU - Roshandel, M. Reza
AU - Lohse, Christine M.
AU - Sharma, Vidit
AU - Thompson, R. Houston
AU - Boorjian, Stephen A.
AU - Leibovich, Bradley C.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/9
Y1 - 2023/9
N2 - Objective: To contrast surgical outcomes of Horseshoe Kidney (HSK) patients with localized renal masses suspected of cancer with nonfused nonectopic kidney patients, emphasizing safe surgical practices for HSKs. Methods: The study examined solid tumors from the Mayo Clinic Nephrectomy registry between 1971 and 2021. Each HSK case was matched to three non-HSK patients based on various factors. The outcomes measured included complications within 30 days of surgery, change in estimated glomerular filtration rate, and overall, cancer-specific, and metastasis-free survival rates. Results: Thirty of the 34 HSKs had malignant tumors compared with 90 of the 102 patients in the nonfused nonectopic referent cohort. Accessory isthmus arteries were present in 93% of HSK cases, with 43% exhibiting multiple arteries and 7% with 6 or more arteries. Estimated blood loss and surgery duration were significantly higher in HSKs (900 vs 300 mL, P = .004; 246 vs 163 minutes, P < .001, respectively). The HSK group demonstrated an overall complication rate of 26% (vs 17% in referents, P = .2) and a median change in estimated glomerular filtration rate at 3 months of − 8.5 (vs − 8.1 in referents, P = .8). At 5-year follow-up, survival rates for HSK patients were 72%, 91%, and 69% for overall, cancer-specific, and metastasis-free survival, respectively. The corresponding rates were 79%, 86%, and 77%, respectively, for matched referent patients (P > .05). Conclusion: HSK tumor management is technically challenging with higher blood loss; however, the data demonstrate comparable outcomes for patients with HSK tumors, including complications and survival, to those without HSKs in experienced centers.
AB - Objective: To contrast surgical outcomes of Horseshoe Kidney (HSK) patients with localized renal masses suspected of cancer with nonfused nonectopic kidney patients, emphasizing safe surgical practices for HSKs. Methods: The study examined solid tumors from the Mayo Clinic Nephrectomy registry between 1971 and 2021. Each HSK case was matched to three non-HSK patients based on various factors. The outcomes measured included complications within 30 days of surgery, change in estimated glomerular filtration rate, and overall, cancer-specific, and metastasis-free survival rates. Results: Thirty of the 34 HSKs had malignant tumors compared with 90 of the 102 patients in the nonfused nonectopic referent cohort. Accessory isthmus arteries were present in 93% of HSK cases, with 43% exhibiting multiple arteries and 7% with 6 or more arteries. Estimated blood loss and surgery duration were significantly higher in HSKs (900 vs 300 mL, P = .004; 246 vs 163 minutes, P < .001, respectively). The HSK group demonstrated an overall complication rate of 26% (vs 17% in referents, P = .2) and a median change in estimated glomerular filtration rate at 3 months of − 8.5 (vs − 8.1 in referents, P = .8). At 5-year follow-up, survival rates for HSK patients were 72%, 91%, and 69% for overall, cancer-specific, and metastasis-free survival, respectively. The corresponding rates were 79%, 86%, and 77%, respectively, for matched referent patients (P > .05). Conclusion: HSK tumor management is technically challenging with higher blood loss; however, the data demonstrate comparable outcomes for patients with HSK tumors, including complications and survival, to those without HSKs in experienced centers.
UR - http://www.scopus.com/inward/record.url?scp=85166307558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85166307558&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2023.06.002
DO - 10.1016/j.urology.2023.06.002
M3 - Article
C2 - 37331487
AN - SCOPUS:85166307558
SN - 0090-4295
VL - 179
SP - 87
EP - 94
JO - Urology
JF - Urology
ER -