Abstract
Purpose of Review: There is considerable interest in using polygenic risk scores (PRSs) for assessing risk of atherosclerotic cardiovascular disease (ASCVD). A barrier to the clinical use of PRSs is heterogeneity in how PRS studies are reported. In this review, we summarize approaches to establish a uniform reporting framework for PRSs for coronary heart disease (CHD), the most common form of ASCVD. Recent Findings: Reporting standards for PRSs need to be contextualized for disease specific applications. Summary: In addition to metrics of predictive performance, reporting standards for PRSs for CHD should include how cases/control were ascertained, degree of adjustment for conventional CHD risk factors, portability to diverse genetic ancestry groups and admixed individuals, and quality control measures for clinical deployment. Such a framework will enable PRSs to be optimized and benchmarked for clinical use.
Original language | English (US) |
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Pages (from-to) | 323-330 |
Number of pages | 8 |
Journal | Current atherosclerosis reports |
Volume | 25 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2023 |
Keywords
- Atherosclerosis
- Atherosclerotic cardiovascular disease
- Coronary heart disease
- Polygenic risk score
- Reporting standards
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine