Implementing individualized medicine into the medical practice

Konstantinos N. Lazaridis, Tammy M. MCAllister, Dusica Babovic-Vuksanovic, Scott A. Beck, Mitesh J. Borad, Alan H. Bryce, Asher A. Chanan-Khan, Matthew J. Ferber, Rafael Fonseca, Kiley J. Johnson, Eric W. Klee, Noralane M. Lindor, Jennifer B. MCCormick, Robert R. MCWilliams, Alexander S. Parker, Douglas L. Riegert-Johnson, Carolyn R. Rohrer Vitek, Kimberly A. Schahl, Cloann Schultz, Keith StewartGeorge C. Then, Eric D. Wieben, Gianrico Farrugia

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Issue number1
StatePublished - Mar 2014


  • Genomic medicine
  • Individualized medicine clinic
  • Personalized medicine
  • Whole exome sequencing

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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