Implantable cardioverter defibrillators in patients with orthotopic heart transplant: A multicenter case series

Waddah Maskoun, Mohamad Raad, Yong Mei Cha, Mahmoud Houmsse, Amjad Abualsuod, Fatima Ezzeddine, Justin Pieper, Khaled Jamoor, Cristina Tita, John Miller

Research output: Contribution to journalArticlepeer-review


Background: Sudden cardiac death (SCD) is common after orthotopic heart transplant (OHT). No clear guidelines for implantable cardioverter defibrillator (ICD) implantation in OHT patients at high risk for SCD currently exist. Objectives: To assess the safety, efficacy, and benefit of ICDs and resynchronization therapy post-OHT. We also provide a systematic review of previous reports. Methods: A retrospective multicenter cohort study within the United States. Patients with ICD post-OHT between 2000 and 2020 were identified. Results: We analyzed 16 patients from 4 centers. The mean standard-deviation (SD) age was 43 (18) years at OHT and 51 (20) years at ICD implantation. The mean (SD) duration from OHT to ICD implantation was 9 (5) years. The mean (SD) left ventricular ejection fraction (LVEF) was 35% (17%). There were 2 (13%) postprocedural complications: 1 hematoma and 1 death. Mean (SD) follow-up was 24 (23) months. Survival rate was 63% (10/16) at 1 year and 56% (9/16) at 2 years, with 6/7 of those who died having LVEF < 35% at the time of the ICD implantation. Patients were more likely to receive appropriate therapy if their ICD was implanted for secondary (5/8) rather than primary (0/8) prevention (p =.007). Of those who did, 4 patients survived to 30 days post-ICD therapy. Severe CAV was not associated with the rate of appropriate therapy. Conclusions: Beneficial outcomes were observed when ICDs were implanted for secondary prevention only, and in patients with higher baseline LVEF. We also observed benefits with resynchronization therapy.

Original languageEnglish (US)
Pages (from-to)1813-1822
Number of pages10
JournalJournal of cardiovascular electrophysiology
Issue number8
StatePublished - Aug 2022


  • advanced heart failure
  • appropriate therapy
  • heart transplantation
  • implantable cardioverter defibrillator
  • sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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