Impaired Muscle Regeneration in Cancer-Associated Cachexia

Paige C. Arneson; Jason D. Doles

doi:10.1016/j.trecan.2019.07.010

Impaired Muscle Regeneration in Cancer-Associated Cachexia

Paige C. Arneson, Jason D. Doles

Biochemistry and Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.

Original language	English (US)
Pages (from-to)	579-582
Number of pages	4
Journal	Trends in Cancer
Volume	5
Issue number	10
DOIs	https://doi.org/10.1016/j.trecan.2019.07.010
State	Published - Oct 2019

Keywords

cachexia
muscle wasting
regeneration
satellite cells

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2019.07.010

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title = "Impaired Muscle Regeneration in Cancer-Associated Cachexia",

abstract = "Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.",

keywords = "cachexia, muscle wasting, regeneration, satellite cells",

author = "Arneson, {Paige C.} and Doles, {Jason D.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

doi = "10.1016/j.trecan.2019.07.010",

language = "English (US)",

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TY - JOUR

T1 - Impaired Muscle Regeneration in Cancer-Associated Cachexia

AU - Arneson, Paige C.

AU - Doles, Jason D.

PY - 2019/10

Y1 - 2019/10

N2 - Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.

AB - Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.

KW - cachexia

KW - muscle wasting

KW - regeneration

KW - satellite cells

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U2 - 10.1016/j.trecan.2019.07.010

DO - 10.1016/j.trecan.2019.07.010

M3 - Short survey

C2 - 31706505

AN - SCOPUS:85070691048

SN - 2405-8033

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EP - 582

JO - Trends in Cancer

JF - Trends in Cancer

IS - 10

ER -

Impaired Muscle Regeneration in Cancer-Associated Cachexia

Abstract

Keywords

ASJC Scopus subject areas

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