Impact of vascular risk factors on brain structure

David S. Knopman, Rosebud Roberts

Research output: Chapter in Book/Report/Conference proceedingChapter


The major vascular risk factors such as diabetes and impaired glycemic control, hypertension, obesity and hyper-or dyslipidemia have been associated both with Alzheimer's disease and vascular dementia. The purpose of this review is to consider how vascular risk factors impact the expression of cognitive impairment in the elderly. The review will focus on how vascular risk factors are associated with changes in brain imaging and neuropathological changes. Midlife diabetes mellitus, hypertension and obesity are the most important vascular risk factors on the basis of their prevalence and associations with late-life cognitive impairment. The basis for their relationships to changes in brain integrity could either be through microvascular brain disease, Alzheimer pathology or both. Midlife vascular risk factors represent potentially modifiable conditions that could mitigate disease in the future.

Original languageEnglish (US)
Title of host publicationHandbook of Imaging the Alzheimer Brain
EditorsJ. Wesson Ashford, Allyson Rosen, Maheen Adamson, Peter Bayley, Ansgar Furst, Osama Sabri, Sandra E. Black, Michael Weiner
Number of pages12
StatePublished - 2011

Publication series

NameAdvances in Alzheimer's Disease
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735


  • Vascular risk factors
  • cognitive impairment
  • dementia
  • diabetes
  • hyperlipidemia
  • hypertension
  • obesity
  • stroke
  • vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology


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