Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: A case report

H. A. Personett; S. L. Larson; E. N. Frazee; S. L. Nyberg; N. Leung; Z. M. El-Zoghby

doi:10.1016/j.transproceed.2014.02.013

Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: A case report

H. A. Personett, S. L. Larson, E. N. Frazee, S. L. Nyberg, N. Leung, Z. M. El-Zoghby

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Abstract

Background We report a unique case which quantifies the effect of molecular adsorbent recirculating system (MARS [Gambro, Sweden]) therapy on blood concentrations of tacrolimus in a patient treated for refractory pruritus associated with recurrent hepatitis C of the liver allograft. Tacrolimus is a low-molecular-weight, highly protein-bound drug with the potential to be removed during MARS therapy.

Case Report Results of therapeutic drug monitoring revealed extracorporeal tacrolimus elimination accounted for only 0.3% of total drug removal during the session.

Conclusions Although no explanation can be offered as to why MARS contributed so little to overall tacrolimus elimination, the data clearly show minimal impact of MARS on tacrolimus blood level.

Original language	English (US)
Pages (from-to)	2440-2442
Number of pages	3
Journal	Transplantation proceedings
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.transproceed.2014.02.013
State	Published - Sep 1 2014

ASJC Scopus subject areas

Surgery
Transplantation

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title = "Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: A case report",

abstract = "Background We report a unique case which quantifies the effect of molecular adsorbent recirculating system (MARS [Gambro, Sweden]) therapy on blood concentrations of tacrolimus in a patient treated for refractory pruritus associated with recurrent hepatitis C of the liver allograft. Tacrolimus is a low-molecular-weight, highly protein-bound drug with the potential to be removed during MARS therapy.Case Report Results of therapeutic drug monitoring revealed extracorporeal tacrolimus elimination accounted for only 0.3% of total drug removal during the session.Conclusions Although no explanation can be offered as to why MARS contributed so little to overall tacrolimus elimination, the data clearly show minimal impact of MARS on tacrolimus blood level.",

author = "Personett, {H. A.} and Larson, {S. L.} and Frazee, {E. N.} and Nyberg, {S. L.} and N. Leung and El-Zoghby, {Z. M.}",

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T1 - Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination

T2 - A case report

AU - Personett, H. A.

AU - Larson, S. L.

AU - Frazee, E. N.

AU - Nyberg, S. L.

AU - Leung, N.

AU - El-Zoghby, Z. M.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background We report a unique case which quantifies the effect of molecular adsorbent recirculating system (MARS [Gambro, Sweden]) therapy on blood concentrations of tacrolimus in a patient treated for refractory pruritus associated with recurrent hepatitis C of the liver allograft. Tacrolimus is a low-molecular-weight, highly protein-bound drug with the potential to be removed during MARS therapy.Case Report Results of therapeutic drug monitoring revealed extracorporeal tacrolimus elimination accounted for only 0.3% of total drug removal during the session.Conclusions Although no explanation can be offered as to why MARS contributed so little to overall tacrolimus elimination, the data clearly show minimal impact of MARS on tacrolimus blood level.

AB - Background We report a unique case which quantifies the effect of molecular adsorbent recirculating system (MARS [Gambro, Sweden]) therapy on blood concentrations of tacrolimus in a patient treated for refractory pruritus associated with recurrent hepatitis C of the liver allograft. Tacrolimus is a low-molecular-weight, highly protein-bound drug with the potential to be removed during MARS therapy.Case Report Results of therapeutic drug monitoring revealed extracorporeal tacrolimus elimination accounted for only 0.3% of total drug removal during the session.Conclusions Although no explanation can be offered as to why MARS contributed so little to overall tacrolimus elimination, the data clearly show minimal impact of MARS on tacrolimus blood level.

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Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: A case report

Abstract

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