Impact of MGUS and myeloma on skeletal health

G. David Roodman, Matthew T. Drake

Research output: Chapter in Book/Report/Conference proceedingChapter


Multiple myeloma (MM) is an incurable plasma cell malignancy that evolves from a premalignant condition termed monoclonal gammopathy of undetermined significance (MGUS). MM is the most frequent cancer that involves the skeleton, with 90% of patients eventually developing bone lesions. Bone involvement causes devastating consequences for MM patients, including pathological fractures that occur in 50%-60% of patients and are present in 20% of patients at diagnosis. These fractures cause severe bone pain and increase mortality risk by 20%. MM increases localized bone resorption and suppresses bone formation, causing purely lytic lesions that usually do not repair. MGUS also affects the skeleton, with MGUS patients having a 1.7-fold increased fracture incidence compared to age-matched controls. In this chapter the mechanisms responsible for the impact of MGUS and MM on the skeleton and therapeutic approaches to prevent and treat MGUS- and MM-induced bone disease are discussed.

Original languageEnglish (US)
Title of host publicationMarcus and Feldman’s Osteoporosis
Number of pages17
ISBN (Electronic)9780128130735
StatePublished - Jan 1 2020


  • Bone disease
  • Bone pain
  • MGUS
  • MMBD
  • Multiple myeloma

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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