Impact of Hospital Volume on Outcomes of Septal Myectomy for Hypertrophic Cardiomyopathy

Kimberly A. Holst, Hartzell V. Schaff, Nicholas G. Smedira, Elizabeth B. Habermann, Courtney N. Day, Vinay Badhwar, Hiroo Takayama, Patrick M. McCarthy, Joseph A. Dearani

Research output: Contribution to journalArticlepeer-review


Background: Left ventricular outflow tract obstruction is common among symptomatic patients with hypertrophic cardiomyopathy, yet septal reduction by surgical myectomy (septal myectomy [SM]) is performed infrequently in many centers. This study examined the possible relationship between institutional case volume and early outcomes of SM. Methods: The Society of Thoracic Surgeons Adult Cardiac Surgery Database was queried for patients with hypertrophic cardiomyopathy who underwent SM from January 2012 to December 2019. The study defined center case volume categories as <1, 1 to 4.99, 5 to 9.99, and ≥10 cases performed on average per year. Results: The study population included 5935 patients at 481 centers with 933 surgeons. The range of average center volume was <1 to 138 cases per year. Overall early mortality was 2.6%, ventricular septal defect (VSD) occurred in 1.9%, and complete heart block occurred in 9.0%. Concomitant mitral valve (MV) repair was performed in 28.7%, and MV replacement was performed in 17.1%. In multivariable analysis, the lowest annual case volume (average <1 case/y) was consistently associated with greater early mortality (odds ratio [OR], 5.4; CI, 3.0-9.9; P <. 001), greater risk of VSD (OR, 9.3; CI, 4.2-20.4; P <. 001), increased incidence of complete heart block (OR, 2.0; CI, 1.5-2.7; P <. 001), and a higher likelihood of MV replacement (OR, 9.4; CI, 7.5-11.8; P <. 001). Conclusions: Volume of SM cases varies widely among institutions reporting to the Society of Thoracic Surgeons Adult Cardiac Surgery Database. There appears to be an important association between surgical experience, as reflected by institutional case volume, and early outcomes, including mortality, as well as the occurrence of VSD, heart block, and MV replacement.

Original languageEnglish (US)
Pages (from-to)2131-2138
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number6
StatePublished - Dec 2022

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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