Impact of gender on the outcome of endovascular aortic aneurysm repair using the zenith stent-graft: Midterm results

Beate Hugl, Albert G. Hakaim, Matthias Biebl, W. Andrew Oldenburg, J. Mark McKinney, Lorraine A. Nolte, Roy K. Greenberg, Timothy A.M. Chuter

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: To analyze the 2-year outcomes of female patients after endovascular aortic aneurysm repair (EVAR) with the Zenith AAA Endovascular Graft. Methods: A retrospective analysis was conducted of data from the US Zenith multicenter trial and the Zenith female registry on 40 women (10.9%, study group) and 326 men (89.1%, control group) enrolled. All patients had completed their 2-year follow-up. Primary study endpoints were survival, aneurysm rupture, and conversion rate. Significance was assumed if p<0.05. Results: Overall rates of mortality (12.5% for women versus 13.2% for men, p=0.94) and aneurysm rupture (2.5% for women versus 0% for men, p=0.11) were comparable between groups. Conversion to open repair within 2 years was significantly more frequent in women compared to men (7.5% versus 0.6%, p=0.01). The incidence of endoleaks of any type was equivalent between groups at 2 years (13.3% for women versus 6.9% for men, p=0.30). No difference was observed in the need for secondary interventions (15% for women versus 13.5% for men, p=0.81) or aneurysm dilatation >5 mm (10.5% for women versus 2.3% for men, p=0.10). None of the patients developed device migration >10 mm or required intervention for migration. Conclusion: While women underwent conversion to open repair more frequently compared to men at 2 years post EVAR, there was no difference in survival, freedom from aneurysm rupture, or need for secondary interventions between groups. As in men, the Zenith AAA Endovascular Graft provides reliable protection from aneurysm rupture and aneurysm-related death in women in a midterm follow-up.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalJournal of Endovascular Therapy
Issue number2
StatePublished - Apr 1 2007


  • Abdominal aortic aneurysm
  • Aneurysm rupture
  • Conversion
  • Endovascular repair
  • Female gender
  • Gender-specific outcomes
  • Mortality

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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