TY - JOUR
T1 - Impact of 1p/19q codeletion status on extent of resection in WHO grade II glioma
T2 - Insights from a national cancer registry
AU - Lu, Victor M.
AU - Alvi, Mohammed Ali
AU - Bydon, Mohamad
AU - Quinones-Hinojosa, Alfredo
AU - Chaichana, Kaisorn L.
N1 - Funding Information:
AQH is funded by the NIH (R01CA183827, R01CA195503, R01CA216855, R01CA200399, R43CA221490), Florida State Department of Health Research, the William J. and Charles H. Mayo Professorship and the Mayo Clinic Clinician Investigator. All other authors report no funding sources or potential conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. The authors report no acknowledgements.
Funding Information:
AQH is funded by the NIH ( R01CA183827 , R01CA195503 , R01CA216855 , R01CA200399 , R43CA221490 ), Florida State Department of Health Research, the William J. and Charles H. Mayo Professorship and the Mayo Clinic Clinician Investigator. All other authors report no funding sources or potential conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/7
Y1 - 2019/7
N2 - Objective: Traditionally, extent of resection (EOR) has been seen as a surgical parameter that can predict survival outcomes of surgically managed WHO grade II gliomas. The aim of this study was to evaluate if such an influence was potentially affected by 1p/19q codeletion status based on a national cancer registry. Patient and methods: All adults diagnosed with grade II gliomas between the years 2004 to 2014 were queried from the National Cancer Database (NCDB). The population was then divided based on 1p/19q codeletion status, and then Kaplan-Meier, univariate and multivariate Cox regression analyses were utilized to evaluate the prognostic effect of EOR. Results: In total, 1,498 grade II gliomas satisfied inclusion for analysis, with the 1p/19q non-codeleted in 705 (47%) cases, and codeletion in 793 (53%) cases. When the cohort was divided based on codeletion status, Kaplan-Meier modelling and univariate regression analyses indicated that gross total resection (GTR) was significantly associated with greater 5-overall survival (OS) in both 1p/19q non-codeleted and codeletion groups. Upon multivariate analysis which incorporated adjuvant therapy status, the significance of GTR was only retained in the 1p/19q non-codeletion group after post-hoc adjustment. Conclusion: Our findings indicate that the survival impact of GTR in grade II gliomas may be affected by 1p/19q codeletion status within the first five years after surgery based on overall survival. Therefore, molecular diagnostics have potential clinical application in surgery outcomes, and validation of the reported findings will assist in surgical planning if such an association can be thoroughly established.
AB - Objective: Traditionally, extent of resection (EOR) has been seen as a surgical parameter that can predict survival outcomes of surgically managed WHO grade II gliomas. The aim of this study was to evaluate if such an influence was potentially affected by 1p/19q codeletion status based on a national cancer registry. Patient and methods: All adults diagnosed with grade II gliomas between the years 2004 to 2014 were queried from the National Cancer Database (NCDB). The population was then divided based on 1p/19q codeletion status, and then Kaplan-Meier, univariate and multivariate Cox regression analyses were utilized to evaluate the prognostic effect of EOR. Results: In total, 1,498 grade II gliomas satisfied inclusion for analysis, with the 1p/19q non-codeleted in 705 (47%) cases, and codeletion in 793 (53%) cases. When the cohort was divided based on codeletion status, Kaplan-Meier modelling and univariate regression analyses indicated that gross total resection (GTR) was significantly associated with greater 5-overall survival (OS) in both 1p/19q non-codeleted and codeletion groups. Upon multivariate analysis which incorporated adjuvant therapy status, the significance of GTR was only retained in the 1p/19q non-codeletion group after post-hoc adjustment. Conclusion: Our findings indicate that the survival impact of GTR in grade II gliomas may be affected by 1p/19q codeletion status within the first five years after surgery based on overall survival. Therefore, molecular diagnostics have potential clinical application in surgery outcomes, and validation of the reported findings will assist in surgical planning if such an association can be thoroughly established.
KW - 1p/19q
KW - Codeletion
KW - Extent of resection
KW - Grade II
KW - Gross total resection
KW - Low grade glioma
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U2 - 10.1016/j.clineuro.2019.04.027
DO - 10.1016/j.clineuro.2019.04.027
M3 - Article
C2 - 31063969
AN - SCOPUS:85065017288
SN - 0303-8467
VL - 182
SP - 32
EP - 36
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
ER -