Immunosuppression: The Global Picture

Russell H. Wiesner

Research output: Chapter in Book/Report/Conference proceedingChapter


The central issue in liver transplantation remains suppression of allograft rejection. Thus, the development of immunosuppressive drugs has been the key to successful allograft function. Immunosuppressive agents are used for induction during the initial days after transplant, during maintenance, and for reversal of established rejection. This chapter centers on the evolution of immunosuppressive therapy over the past three decades. It discusses how the strategy and goals of immunosuppression have changed over the years. Finally, the ultimate goal of tolerance is touched on and the future is considered for the possible individualization of immunosuppressive drugs to reduce not only the rates of rejection but, more importantly, to minimize toxicity.

Original languageEnglish (US)
Title of host publicationSchiff's Diseases of the Liver
Number of pages14
ISBN (Print)0470654686, 9780470654682
StatePublished - Oct 31 2011


  • Alloreactivity
  • Antimetabolites
  • Calcineurin inhibitors
  • Endotheliitis
  • Immunosuppressive drugs
  • Lymphocyte-depleting antibodies
  • MTOR inhibitors
  • Nonlymphocyte-depleting antibodies
  • Rejection cholangitis
  • Three signal pathway
  • Tolerance

ASJC Scopus subject areas

  • Medicine(all)


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