Immunosenescence: Role and measurement in influenza vaccine response among the elderly

Paul V. Targonski, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysfunction may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. Mounting biological evidence supports the potential clinical relevance and impact of immunosenenscence. We briefly review immunosenescence with a focus on replicative senescence in cytotoxic T cells and recent clinical studies examining its association with influenza and infectious disease outcomes.

Original languageEnglish (US)
Pages (from-to)3066-3069
Number of pages4
Issue number16 SPEC. ISS.
StatePublished - Apr 20 2007


  • Immunosenescence
  • Influenza
  • Telomerase

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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