Immunoregulatory cell dysfunction in chronic B-cell leukemias

S. L. Zaknoen, N. E. Kay

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Chronic B-cell malignancies are routinely characterized as B-cell clonal diseases that have signs and symptoms primarily related to the continuing expansion of these cells. This review discusses chronic lymphocytic leukemia, multiple myeloma and hairy cell leukemia from the perspective of secondary abnormalities in non-malignant cells. Thus, our main purpose is to elaborate on the alterations/abnormalities of the immunoregulatory (IR) cells in these diseases and focus on the qualitative and quantitative aspects of T-cells, natural killer (NK) cells and monocytes. The relevance of the IR-cell changes to the basic disease process and their complications are emphasized.

Original languageEnglish (US)
Pages (from-to)165-174
Number of pages10
JournalBlood Reviews
Issue number3
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Hematology
  • Oncology


Dive into the research topics of 'Immunoregulatory cell dysfunction in chronic B-cell leukemias'. Together they form a unique fingerprint.

Cite this