Immunopathogenesis of autoimmune diseases

De Lisa Fairweather, Noel R. Rose

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


The immune system specifically recognizes and eliminates foreign antigens thereby protecting the host against infection. During maturation of the immune system lymphocytes specific for the universe of possible antigens arise, but tolerance mechanisms minimize harmful responses against self-tissues. However, the inappropriate activation of surviving self-reactive T or B lymphocytes can result in systemic or organ-localized autoimmune damage.

Original languageEnglish (US)
Title of host publicationImmunotoxicology and Immunopharmacology, Third Edition
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781420005448
ISBN (Print)9780849337901
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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