Abstract
Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in high-throughput technologies provide an opportunity to monitor the dynamic and complex immune system, which may to lead to a more personalized treatment approach in IBD.
Original language | English (US) |
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Pages (from-to) | 405-424 |
Number of pages | 20 |
Journal | Gastroenterology Clinics of North America |
Volume | 43 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2014 |
Keywords
- Adaptive immunity
- Biologics
- IBD
- Immunology
- Innate immunity
ASJC Scopus subject areas
- Gastroenterology