Immunological responses of guinea pigs to a synthetic autoantigen of brain

Vanda A. Lennon, P. R. Carnegie

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A synthetic peptide, Ser‐Arg‐Phe‐Ser‐Trp‐Gly‐Ala‐Glu‐Gly‐Gln‐Arg, of identical sequence to residues 112 to 122 of the basic protein of human myelin was active in guinea pigs in inducing experimental autoimmune encephalomyelitis. This peptide did not induce a humoral immune response, but a cellular immune response was obtained, as judged by transformation of splenic lymphocytes when these were cultured with the human encephalitogenic protein, and by demonstration of macrophage inhibitory factor when peritoneal exudate cells were incubated with the protein.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalEuropean Journal of Immunology
Issue number1
StatePublished - Jan 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Immunological responses of guinea pigs to a synthetic autoantigen of brain'. Together they form a unique fingerprint.

Cite this