Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021

M. Hasib Sidiqi, Morie A. Gertz

Research output: Contribution to journalReview articlepeer-review


Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients presenting with these symptoms. More importantly, patients being monitored for smoldering multiple myeloma and a monoclonal gammopathy of undetermined significance (MGUS) are at risk for developing AL amyloidosis. MGUS and myeloma patients that have atypical features, including unexplained weight loss; lower extremity edema, early satiety, and dyspnea on exertion should be considered at risk for light chain amyloidosis. Overlooking the diagnosis of light chain amyloidosis leading to therapy delay is common, and it represents an error of diagnostic consideration. Herein we provide a review of established and investigational treatments for patients with AL amyloidosis and provide algorithms for workup and management of these patients.

Original languageEnglish (US)
Article number90
JournalBlood cancer journal
Issue number5
StatePublished - May 2021

ASJC Scopus subject areas

  • Hematology
  • Oncology


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